Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

MR Olson; SGK Seah; J Cullen; M Greyer; K Edenborough; PC Doherty; S Bedoui; AM Lew; SJ Turner

Journal article

Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

MR Olson, SGK Seah, J Cullen, M Greyer, K Edenborough, PC Doherty, S Bedoui, AM Lew, SJ Turner

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2014

DOI: 10.4049/jimmunol.1303359

Abstract

Although CD4+ T cell help (Th) is critical for inducing optimal B cell and CD8+ T cell responses, it remains unclear whether induction of CD4+ Th responses postinfection are also dependent on CD4+ T cell help. In this study, we show that activation of adoptively transferred Th cells during primary influenza A virus (IAV) infection enhances both the magnitude and functional breadth of endogenous primary IAV-specific CD4+ T cell responses. This enhancement was dependent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of IAV-specific CD4+ and CD8+ T memory responses after heterologous IAV infection. These data suggest that engaging pre-existing CD4 res..

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University of Melbourne Researchers

Kathryn Edenborough Author

Peter Doherty Author

Sammy Bedoui Author

Andrew Lew Author

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Grants

Funding Acknowledgements

This work was supported by Australian National Health and Medical Research Council (NHMRC) Program Grants 5671222 (to P.C.D. and S.J.T.) and 1037321 (to A.M.L.), NMHRC Project Grant 1043414 (to A.M.L.), NHMRC Project Grant 628651 and 1059937 (to S.B.), Juvenile Diabetes Research Foundation Grant 112613 (to A.M.L.), the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institutes Infrastructure Support (to A.M.L.), a DSO National Laboratories Scholarship, Singapore (to S.G.K.S.), and an Australian Research Council Future Fellowship (to S.J.T.).